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Eosinophilic cholecystitis

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Restrict usage to inflammatory infiltrates composed almost entirely of eosinophils, since eosinophils are common in subacute cholecystitis
● 1-5% of resected gallbladders
● Often involves muscular layer, but may be transmural or mucosal
● Associated with gallstones, fibroblasts
● Churg-Strauss syndrome: granulomatous angiitis with eosinophilia


● Idiosyncratic reaction to biliary contents
● Less commonly due to ampicillin, atopy, cephalosporin, eosinophilic cholangitis, eosinophilic enterocolitis or appendicitis, erythromycin, hypereosinophilic syndrome, interleukin 2 and lymphokine activated killer cells, lymphoplasmacytic sclerosing pancreatitis, parasitic infection, peripheral eosinophilia (Am J Surg Pathol 2003;27:334)

Case reports

● 29 year old obese man (Ann Clin Lab Sci 2007;37:182)
● 40 year old woman with Ascariasis-induced eosinophilic cholecystitis (HPB (Oxford) 2006;8:72)
● 40 year old woman (Cir Esp 2012 May 5 [Epub ahead of print])

Clinical images

Various images

Gross images

Various images

Micro images

Various images

End of Gallbladder > Cholecystitis > Eosinophilic cholecystitis

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