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Malignant gallbladder tumors

Carcinoma in situ

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Often an incidental finding after cholecystectomy for cholecystitis or cholelithiasis (Arch Pathol Lab Med 2010;134:1621)
● Not associated with tumor related death

Micro description

● May extend into Rokitansky-Aschoff sinuses resembling invasive carcinoma, but is connected to surface epithelium (Am J Surg Pathol 2004;28:621)
● Mixture of benign and neoplastic epithelium
● Has inspissated bile in long dilated spaces
● Desmoplasia, but no invasion into smooth muscle bundles, no perineurial invasion
● May arise in adenomyomatous hyperplasia

Comparison of CIS with invasive carcinoma

Micro images

Various images

End of Gallbladder > Malignant gallbladder tumors > Carcinoma in situ

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