Eye
Uvea (iris, choroid and ciliary body), limbus and sclera
Lisch nodule
Author: Nat Pernick, M.D.
Last author update: 1 October 2014
Last staff update: 1 December 2020
Copyright: 2004-2025, PathologyOutlines.com, Inc.
PubMed Search: Lisch nodules [title] iris
Table of Contents
Definition / general | Clinical images | Microscopic (histologic) description | Positive stains | Differential diagnosisCite this page: Pernick N. Lisch nodule. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeuvealisch.html. Accessed January 21st, 2025.
Definition / general
- Pigmented iris hamartomas
- Associated with neurofibromatosis type 1, also familial angiolipomatosis, a benign condition with no malignant potential (Arch Pathol Lab Med 1999;123:946)
Clinical images
Images hosted on other servers:
Lisch nodules
Microscopic (histologic) description
- Dome shaped papules on anterior surface of iris consisting of aggregates of ovoid to round cells
Differential diagnosis
- Iris melanoma
- Neurofibromatosis
- Nevi
- Trauma
