Eye
Lens & vitreous humor
Phacoanaphylactic endophthalmitis
Author: Nat Pernick, M.D.
Last author update: 1 February 2014
Last staff update: 28 December 2020
Copyright: 2004-2024, PathologyOutlines.com, Inc.
PubMed Search: Phacoanaphylactic endophthalmitis [title]
Cite this page: Pernick N. Phacoanaphylactic endophthalmitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyelensphacoanaphylaxis.html. Accessed April 19th, 2024.
Definition / general
- Usually occurs after penetrating injuries to lens
- Rarely due to spontaneous rupture of swollen lens with a cataract
- Granulomatous reaction may be due to acquired hypersensitivity to lens proteins
- May coexist with sympathetic uveitis
Microscopic (histologic) description
- Granulomatous inflammation surrounding area of lens perforation, with zonal pattern of central neutrophils around disintegrating lens fibers and peripheral macrophages, epithelioid cells and giant cells
- Posterior synechiae usually present
- Usually perivasculitis of retinal vessels
- Variable plasma cells in iris
