Eye
Lens & vitreous humor
Persistent hyperplastic primary vitreous
Author: Nat Pernick, M.D.
Last author update: 1 February 2014
Last staff update: 27 May 2022
Copyright: 2004-2025, PathologyOutlines.com, Inc.
PubMed Search: Persistent hyperplastic primary vitreous
Table of Contents
Definition / general | Radiology images | Gross images | Clinical images | Microscopic (histologic) description | Whole mount images | Microscopic (histologic) images | Differential diagnosisCite this page: Pernick N. Persistent hyperplastic primary vitreous. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyelenspersistenthyperplasticprimaryvitreous.html. Accessed April 1st, 2025.
Definition / general
- Congenital, due to incomplete regression of fetal vasculature of vitreous humor, producing a retrolental mass
- Usually unilateral
- Associated with small eye, white reflex behind pupil (leukokoria), fibrous tissue behind lens, often cataract
- Retina normal or with retinal dysplasia
Radiology images
AFIP images
CT scan: microphthalmic eye
Gross images
AFIP images
Mild microphthalmos
Clinical images
AFIP images
Wrinkling and rupture of posterior lens capsule
Microscopic (histologic) description
- Dense fibrovascular retrolental mass containing elongated ciliary processes and part of hyaloid vascular system
Whole mount images
AFIP images
Falciform fold of detached dysplastic retina
Microscopic (histologic) images
AFIP images
Retrolental mass
Retrolental fibrovascular mass
Differential diagnosis
- Retinoblastoma:
- Also produces white reflex
