Ectopic gastric tissue
Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 10 June 2013, last major update August 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Also called gastric heterotopia, cervical inlet patch
- Most common form of heterotopia
- Usually in postcricoid region (may be difficult to examine endoscopically, South Med J 2006;99:865), found in 1-4% endoscopically (J Gastroenterol Hepatol 2004;19:891, Int J Clin Pract 2009;63:287)
- May be due to rests of gastric precursor cells that remain after original esophageal mucosa is replaced by stratified squamous epithelium
- May cause dysphagia or heartburn
- Associated with H. pylori (29-77%, Am J Gastroenterol 2003;98:1266), esophagitis and Barrett’s esophagus (20%, Arch Pathol Lab Med 2004;128:444)
- Barrett’s has similar mucin profile (Hum Pathol 1988;19:1301) and keratin expression (Am J Surg Pathol 2005;29:437)
- Classified based on symptoms and morphologic changes (Am J Gastroenterol 2004;99:543)
- Complications: ulceration, bleeding, stricture or perforation from acid secretion; rarely adenocarcinoma
- Endoscopy: round to oval, red-orange-salmon flat area referred to as "inlet patch"
- Resembles gastric mucosa with sharp border from normal squamous epithelium; deep pink and velvety
- Usually cardiac-fundic glands with parietal and chief cells, often extensive inflammation causing reactive changes
- May ulcerate
Mucosal biopsy shows antral type mucosa
and a small fragment of squamous epithelium
Salmon colored patch
End of Esophagus > Congenital anomalies > Ectopic gastric tissue
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