Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 12 June 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Cannot definitely diagnose on biopsy, need resection specimen; however, can suggest diagnosis with appropriate findings
- Associated with GI Crohn’s disease; esophageal involvement in 0.2-13% with ileocolic Crohn's disease
- Usually extraesophageal Crohn’s disease at time of presentation in esophagus (Inflamm Bowel Dis 2001;7:113)
- Isolated esophageal involvement is extremely rare; when first diagnosed in esophagus, intestinal involvement usually follows
- Clinical and endoscopic appearances are highly variable and may not correlate (J Pediatr Gastroenterol Nutr 2003;36:454)
- Early - mucosal hyperemia and aphthous ulcers
- Late - discrete ulcers of lower 2/3, fibrosis, stenosis, fistulas
- Deep and aphthoid ulcers, transmural inflammation, non-necrotizing granulomas, epithelioid non-necrotizing granulomas in 7-9% (Am J Gastroenterol 1997;92:1467)
End of Esophagus > Esophagitis > Crohn's disease
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