Colon tumor
Mesenchymal tumors
Pyogenic granuloma of colon

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 10 July 2017, last major update June 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: colonic pyogenic granuloma

Cite this page: Pyogenic granuloma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/colontumorpyogenicgranuloma.html. Accessed July 23rd, 2017.
Definition / general
  • Benign capillary hemangioma forming a colonic polyp
Essential features
  • Very rare
  • Can cause rectal bleeding
Terminology
  • Also called lobular capillary hemangioma
Sites
  • Usually occurs in skin or oral cavity; gastrointestinal tract cases are very rare
Clinical features
  • Presents clinically as rectal bleeding and anemia
Case reports
Clinical images

Images hosted on other servers:

Colonoscopy



Jejunal pyogenic granuloma

Upper duodenum findings

Endoscopic duodenal mucosal resection

Gross description
  • Pedunculated or sessile polyp
  • May appear black and necrotic
Microscopic (histologic) description
  • Lobular arrangement of capillaries within edematous, inflamed stroma
  • Endothelial cells often swollen
  • Often shows surface ulceration; sometimes shows mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

High power H&E

IHC for CD31 and CD34



Duodenum-edematous granulation tissue

Jejunum-postsurgical pyogenic granuloma

Jejunum-CD34

Positive stains
Differential diagnosis
Board review question #1
A 21-year old man presents to his physician, complaining of hematochezia. Colonoscopy shows a small, pedunculated polyp. Microscopically, the polyp is mostly composed of inflammation and small blood vessels. Which of the following findings would favor a diagnosis of pyogenic granuloma?

A. Dilated, ectatic crypts
B. Lobular architecture
C. Positivity for HHV8
D. Surface adenomatous change
E. Viral cytopathic effect
Board review answer #1
B. Lobular architecture