Colon tumor
Carcinoma
Neuroendocrine carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 3 January 2017, last major update June 2015

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Neuroendocrine carcinoma [title] colon
Cite this page: Neuroendocrine carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/colontumorneuroendocrine.html. Accessed September 21st, 2017.
Definition / general
Terminology
  • Two types, based on morphology: large cell neuroendocrine carcinoma (discussed herein) and small cell carcinoma (discussed here)
Epidemiology
  • Disease typically presents at advanced stage, in patients often younger than those with colorectal adenocarcinoma (Dis Colon Rectum 2004;47:163)
Sites
  • Can arise anywhere along the colon or rectum
Prognostic factors
  • Good prognostic factors include peritumoral lymphocytes, microsatellite instability and pure large cell features; poor prognostic factors include CD117 positivity and vascular invasion (Am J Surg Pathol 2012;36:601)
Clinical images

Images hosted on other servers:

Rectal mass

Noncontrast CT scans of abdomen

Microscopic (histologic) description
  • Organoid arrangement of cells larger than those in small cell carcinoma, with nuclear pleomorphism and hyperchromasia, prominent nucleoli, numerous mitoses and tumor necrosis
Microscopic (histologic) images

Images hosted on other servers:

H&E, synaptophysin, chromogranin, Ki67

Large cell neuroendocrine carcinoma

ChromograninA, CK20

Ampulla of vater

Cervix

Positive stains
Differential diagnosis