Colon tumor
Hepatoid carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 2 January 2017, last major update April 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: "Hepatoid carcinoma" colon

Cite this page: Hepatoid carcinoma. website. Accessed March 29th, 2017.
Definition / General
  • Rare, aggressive subtype of adenocarcinoma that morphologically resembles hepatocellular carcinoma and produces alpha fetoprotein
  • Originally termed "alpha fetoprotein producing tumor"
  • More common in men
  • Fewer than 20 colonic cases reported
Clinical Features
Case Reports
Micro Description
  • Resembles hepatocellular carcinoma, with trabecular or solid pattern of large polygonal cells with abundant eosinophilic or clear cytoplasm
  • Component of traditional adenocarcinoma also often present
  • Lymphovascular invasion is common (Histopathology 1997 Jul;31:47)
Micro Images

Images hosted on other servers:

Collision with liposarcoma

Associated with ulcerative colitis

Gastric tumor: H&E, AFP+ Hep Par 1- glypican3+

Differential Diagnosis