Colon non tumor
Non-neoplastic, non-congenital lesions
Colitis cystica profunda

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 10 January 2017, last major update August 2013

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: colitis cystica profunda
Cite this page: Colitis cystica profunda. PathologyOutlines.com website. http://pathologyoutlines.com/topic/coloncystitiscystica.html. Accessed November 17th, 2017.
Definition / general
  • Reactive mucosal change characterized by submucosal mucin filled cysts lined by benign epithelium
Terminology
  • Also called colitis cystica polyposa or hamartomatous inverted polyp when presents as polypoid lesion
Epidemiology
  • Uncommon; male predilection
Sites
  • Can occur anywhere in GI tract, including stomach ("gastritis cystica profunda") and small intestine ("enteritis cystica profunda")
Pathophysiology
  • Secondary to mucosal damage due to ulcerative colitis, Crohn disease, radiation, diverticulitis or other inflammation / ulceration of bowel; mucus follows granulation tracts to involve large areas of bowel
Clinical features
  • Stools contain blood or mucus; patients may have diarrhea or abdominal pain
Radiology description
Case reports
Treatment
  • Patient education to avoid straining, high fiber diet with bulk laxatives, surgery for rectal prolapse
Clinical images

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Barium imaging shows filling defect

Gross description
  • May appear as a polypoid or submucosal mass
Gross images

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Submucosal abnormality

Polypoid mass in sigmoid colon

Microscopic (histologic) description
  • Either localized or diffuse; similar histology to colorectal polyps in Cowden syndrome although "inverted"
  • Misplaced benign colonic epithelium forming cystic spaces filled with mucin and surrounded by lamina propria; mucin may extravasate into surrounding tissue
Microscopic (histologic) images

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Deep dilated glands with surrounding fibrosis

Differential diagnosis