Colon non tumor
Colitis (non-infectious)
Brainerd diarrhea

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 December 2016, last major update May 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: brainerd diarrhea
Cite this page: Brainerd diarrhea. PathologyOutlines.com website. http://pathologyoutlines.com/topic/colonbrainerd.html. Accessed May 22nd, 2017.
Definition / general
  • Chronic watery diarrhea of unknown etiology with acute onset and long duration (Centers for Disease Control, Wikipedia)
  • First case in 1983 in Brainerd, Minnesota (USA)
  • Similar to epidemic infectious diarrhea, but symptoms usually last 4+ weeks, often years
  • Most patients recover within 3 years or less
Case reports
Microscopic (histologic) description
  • Surface epithelial lymphocytosis (similar to lymphocytic colitis) with no architectural distortion, no degenerative changes, no thickened subepithelial collagen (Am J Surg Pathol 1996;20:1102)