Table of ContentsDefinition / General | Epidemiology | Etiology | Clinical Features | Diagnosis | Treatment | Diagrams / Tables | Micro Images | Additional References
Cite this page: Inflammatory bowel disease-general. PathologyOutlines.com website. http://pathologyoutlines.com/topic/colonIBCgeneral.html. Accessed March 26th, 2017.
Definition / General
- Possible causes: alteration in usual steady state between immune system (activated by microbes, antigens and endogenous inflammatory stimuli) and host defenses that maintain integrity of mucosa and down-regulate inflammation (Inflamm Bowel Dis 2006;12:S3, Nat Clin Pract Gastroenterol Hepatol 2006;3:390)
- Often coexists with diverticular disease; presence of Crohn's in diverticular disease is suggested by fissuring ulcers, ulcers outside areas of active diverticulitis and fistulas other than colovesicle or colovaginal; most patients don't develop other IBD lesions
- Requires clinicopathologic correlation; pathologist should convey histologic findings to clinician, who correlates with clinical history, endoscopy, radiology; disease may be difficult to classify (Histopathology 2006;48:116)
- Immunosuppressive therapy