Colon non tumor
Congenital anomalies
Epidermolysis bullosa dystrophica

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 13 December 2016, last major update May 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Epidermolysis bullosa dystrophica
Cite this page: Epidermolysis bullosa dystrophica. PathologyOutlines.com website. http://pathologyoutlines.com/topic/colonEpidermolysisbullosadystrophica.html. Accessed March 30th, 2017.
Definition / General
  • Commonly causes constipation
Case Reports
  • 35 year old man with fecal impaction causing toxic megacolon and death from perforation (BMC Dermatol 2006;6:2)
Micro Description
  • Colonic biopsy: abundance of karyorrhectic cellular debris is located within lamina propria (beneath the surface epithelium); patchy granular brown, hemosiderin pigment containing macrophages in lamina propria (J Clin Pathol 2007;60:843)
Micro Images

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Colonic mucosal biopsy specimens

Positive Stains
  • Type VII collagen (COL7) is expressed in different portions of gut and anti-COL7 antibodies may induce GI damage (J Pathol 2011;224:234)