Table of ContentsDefinition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains
Cite this page: Epidermolysis bullosa dystrophica. PathologyOutlines.com website. http://pathologyoutlines.com/topic/colonEpidermolysisbullosadystrophica.html. Accessed January 19th, 2018.
Definition / general
- Commonly causes constipation
- 35 year old man with fecal impaction causing toxic megacolon and death from perforation (BMC Dermatol 2006;6:2)
Microscopic (histologic) description
- Colonic biopsy: abundance of karyorrhectic cellular debris is located within lamina propria (beneath the surface epithelium); patchy granular brown, hemosiderin pigment containing macrophages in lamina propria (J Clin Pathol 2007;60:843)
- Type VII collagen (COL7) is expressed in different portions of gut and anti-COL7 antibodies may induce GI damage (J Pathol 2011;224:234)