CNS tumor
Germ cell tumors
Teratoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Teratoma of the CNS [title]

Cite this page: Pernick, N. Teratoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumorteratoma.html. Accessed October 23rd, 2017.
Definition / general
  • Tissue derived from ectoderm, endoderm and mesoderm (at least 2 of 3 germinal layers)
  • Usually well differentiated / grade I of IV
  • Incidence varies with age: 30 - 50% of congenital brain tumors, 2% of brain tumors in infants and children, 0.5% at all ages
  • Congenital cases are usually fatal; may replace cerebral hemispheres (Pediatr Pathol 1987;7:333)
  • Mature teratomas:
    • Have well differentiated tissue from all three germinal layers, including neuroectoderm, epithelium (solid, cystic, glandular or tubular), cartilage or other mesenchymal elements, glial and neuronal tissue
  • Immature teratomas:
    • Have less differentiated tissue from any of the three germinal layers
    • 50% with intracranial tumors die within one year
    • Pineal teratomas are more common in males but saccrococcygeal teratomas are more common in females
    • Must sample thoroughly for correct diagnosis
Terminology
Poor prognostic factors
  • Tissue resembling medulloepithelioma, neuroblastoma, retinoblastoma or ependymoblastoma
Case reports
Treatment
  • Newborns - complete surgical excision (difficult)
Gross images

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Mass (thick arrows) and brain (thin arrows)