CNS tumor
Meningeal tumors
Secretory meningioma

Author: Jesse Kresak, M.D. (see Authors page)
Editor: Anthony T. Yachnis, M.D.

Revised: 6 September 2017, last major update April 2014

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: "Secretory meningioma"

Cite this page: Kresak, J. Secretory meningioma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumorsecretorymeningioma.html. Accessed December 15th, 2017.
Definition / general
Radiology description
Radiology images

Images hosted on other servers:

Cystic changes

Heterogeneous strong enhancement

Axial T1 weighted

Typical "xenon light"


Peritumoral brain edema

Axial Gd-DTPA enhanced images

High resolution CT

Postcontrast T1 WI MRI

Case reports
Gross description
  • Dural based of variable size
Microscopic (histologic) description
  • Intracellular lumina with eosinophilic, granular or hyalinized secretions referred to as "pseudopsammoma bodies"
  • Secretions are PAS+ and CEA+
  • Additional areas have classic meningioma histology
  • May have abundant mast cells (Neurosurg Rev 2006;29:41)
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #325:

H&E


PASD

EMA

NSE



Images hosted on other servers:

Dura

Classic vs. secretory meningioma

Various images

Pseudo-psammoma bodies, H&E


Cells with lumina containing PAS+ inclusions

H&E and PAS


CEA

Trichrome

Alcian blue

Cytokeratin

Cytology description
  • Hypercellular cohesive clusters of uniformly dense cells with eosinophilic cytoplasm, smooth nuclear outlines and even chromatin
  • Also cells with syncytial arrangements, whorls and nuclear pseudoinclusions (Acta Cytol 1999;43:121)
Cytology images

Images hosted on other servers:

Various images

Positive stains
  • Secretions positive for PAS and CEA
  • Tumor cells surrounding secretions are positive for CEA and sometimes cytokeratin
  • EMA, PR
Negative stains
Electron microscopy description
  • Hyaline inclusions are intracellular and within intercellular lumina lined by microvilli; inclusions contain granular material forming a dense core
  • Also microvesicles, dense bodies and lamellar structures
Molecular / cytogenetics description