CNS tumor
Tumors of the sellar region
Pituitary adenoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: "Pituitary adenoma" CNS

Cite this page: Pernick, N. Pituitary adenoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumorpituitaryadenoma.html. Accessed October 23rd, 2017.
Definition / general
  • May grow into base of brain and resemble oligodendroglioma, ependymoma or meningioma
  • May be nonfunctional, particularly if gonadotropin producing (no increase in plasma hormones)
  • Invasion of sella is associated with prolactin production (Arch Neurol 1977;34:742)
  • Most grow slowly and are considered benign but others with benign histologic features invade the cavernous sinus, sphenoid sinus and base of brain
  • Often classified by hormone production (growth hormone, prolactin, TSH, ACTH, FSH or alpha glycoprotein subunit)
  • Adenoma with uncertain malignant potential: high Ki67, p53+ or invasive but not metastatic
Case reports
Microscopic (histologic) images

Images hosted on other servers:

Sheets of round cells

Positive stains
Electron microscopy description
  • Neurosecretory granules