CNS tumor
Lymphoma and other hematopoietic lesions
Lymphomatoid granulomatosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Lymphomatoid granulomatosis CNS

Cite this page: Pernick, N. Lymphomatoid granulomatosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumorlymphomatoidgranulomatosis.html. Accessed December 12th, 2017.
Definition / general
  • Lymphoproliferative disorder with features of inflammation, vasculitis and neoplasm; usually B cell disorder with reactive T cells
  • Has high rate of CNS involvement (20 - 50%), often associated with pulmonary disease
  • Rarely is isolated to CNS
  • May progress to lymphoma, particularly in AIDS patients
Microscopic (histologic) description
  • Angiocentric inflammation due to atypical lymphocytes with vessel wall destruction
  • Usually no well formed granulomas
Microscopic (histologic) images

Images hosted on other servers:

Perivascular lymphocytes, microglia and macrophages

Perivascular small lymphocytes with atypia

Positive stains
Additional references