CNS tumor
Neuronal and mixed neuronal - glial tumors
Extraventricular neurocytoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 August 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Extraventricular neurocytoma [title]

Cite this page: Pernick, N. Extraventricular neurocytoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumorextraventricularneurocytoma.html. Accessed December 12th, 2017.
Definition / general
Radiology description
  • Circumscribed, solitary and 57% cystic
Prognostic factors
  • Poor prognostic factors: incomplete excision, atypical features, high cell proliferation rates; also older patient age
Case reports
Treatment
  • Total excision prevents recurrence
Microscopic (histologic) description
  • Sheets, clusters, ribbons or rosettes of monotonous tumor cells with round and regular vesicular nuclei and distinct nucleoli embedded in matrix of fine neuropil
  • Ganglion cells in 66%
  • Atypical if necrosis, vascular proliferation and 3+ mitotic figures/10 HPF
Positive stains
  • Synaptophysin (strong), GFAP (46%; also is staining of entrapped astrocytes at periphery)
Electron microscopy description
  • Neuritic type processes with microtubules, dense core granules
Differential diagnosis
  • Ependymoma
  • Oligodendroglioma: no ganglion cell differentiation, no salt and pepper chromatin and no neuropil islands; usually more infiltrative, synaptophysin-