Diffuse astrocytoma - gemistocytic
Reviewers: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 29 February 2012, last major update February 2012
Copyright: (c) 2005-2012, PathologyOutlines.com, Inc.
● Variant in which gemistocytes constitute > 20% of tumor cells
● Congenital brain tumor (University of Pittsburgh Case 368)
Frontal lobe tumor
Micro description (Histopathology)
● Infiltrative tumor with gemistocytes, characterized by ample eosinophilic glassy cytoplasm and eccentric nuclei with frequent prominent nucleoli
● Background is coarse fibrillary; perivascular lymphocyte cuffing is common
Astrocytes with abundant eosinophilic cytoplasm
● GFAP, vimentin
● Gliosis: hypertrophy of cells rather than hyperplasia, even distribution
● Subependymal giant cell tumor: intraventricular, larger nuclei, non-infiltrative
● Ganglioglioma: neoplastic neurons
End of CNS tumor > Diffuse astrocytoma - gemistocytic
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