Diffuse astrocytoma - fibrillary
Reviewers: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 29 February 2012, last major update February 2012
Copyright: (c) 2005-2012, PathologyOutlines.com, Inc.
● The most frequent variant of diffuse astrocytoma
Micro description (Histopathology)
● Fibrillary astrocytes with naked, atypical, elongated, irregular, hyperchromatic nuclei embedded in a fibrillary background
● Microcysts are common
● Some gemistocytes may be admixed
The processes of these star-shaped cells form a felt-like perivascular mantle
All astrocytomas have a tendency, as in this case, to appear microcystic
Well differentiated tumor is HAM56 negative (no macrophages)
Smear shows neoplastic astrocytes with cytoplasmic glial processes and variable nuclear atypia
● GFAP, PTAH
● Gliosis: hypertrophy of cells rather than hyperplasia, even distribution
● Oligodendroglioma grade II: uniformly rounded nuclei with small distinct nucleoli, perinuclear halos, chicken wire vessels, calcification, GFAP negative
End of CNS tumor > Diffuse astrocytoma - fibrillary
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