CNS & pituitary tumors
Gliomas, glioneuronal tumors and neuronal tumors
Pediatric type diffuse low grade gliomas
Angiocentric glioma
Author: Eman Abdelzaher, M.D., Ph.D.
Last author update: 1 March 2013
Last staff update: 9 August 2023
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Angiocentric glioma
Table of Contents
Definition / general | Epidemiology | Clinical features | Grading | Radiology description | Radiology images | Prognostic factors | Case reports | Treatment | Gross description | Microscopic (histologic) description | Positive stains | Differential diagnosis | Additional referencesCite this page: Abdelzaher E. Angiocentric glioma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorangiocentricglioma.html. Accessed December 21st, 2024.
Definition / general
- Superficial cerebrocortical tumour with features of infiltrating astrocytoma and ependymoma
- Relationship to ependymoma is unclear
Epidemiology
- Primarily children and young adults
- Wide age range (2 to 70 years, mean 17 years)
- Affect both sexes equally
Clinical features
- Seizures are characteristic
Grading
- WHO grade 1
- Criteria for higher grade lesions are unclear
Radiology description
- Well delineated, solid, hyperintense, nonenhancing cortical lesions
- Stalk-like extension to adjacent ventricle is diagnostic
Radiology images
Images hosted on other servers:
Axial MR images
Axial T1 and T2 weighted MR images
Hyperintense cortically based mass
Prognostic factors
- Generally favorable with rare recurrence
Case reports
- 3 cases: children 10, 10 and 13 years old (J Neurosurg Pediatr 2009;3:197)
Treatment
- Surgical excision
- Role of chemo or radiotherapy is unclear
Gross description
- Ill defined, firm
Microscopic (histologic) description
- Infiltrative, monomorphous, bipolar spindled cells arranged in angiocentric pattern about cortical blood vessels
- Also ependymoma-like pseudorosettes, subpial palisading, accumulation of tumor cells, miniature schwannoma-like nodules
- Usually no mitoses, no vascular proliferation, no necrosis
- Mitotically active lesions are associated with increased risk of recurrence
Differential diagnosis
- Astroblastoma:
- Discrete borders, epithelioid cells, vascular sclerosis
- Astrocytoma, infiltrating:
- No pseudorosettes or subpial palisading
- Ependymoma:
- Enhancing, discrete borders
Additional references
