CNS tumor
Lymphoma and other hematopoietic lesions
Anaplastic large cell lymphoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: "Anaplastic large cell lymphoma" CNS

Cite this page: Pernick, N. Anaplastic large cell lymphoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumoranaplasticlargecelllymphoma.html. Accessed October 20th, 2017.
Definition / general
  • Rare in CNS (either primary or secondary)
  • Aggressive (rapidly fatal)
  • Favorable prognostic factors: ALK1+, young age (Am J Surg Pathol 2003;27:487)
Case reports
Microscopic (histologic) description
  • Large lymphoid cells with abundant cytoplasm and pleomorphic nuclei, often horseshoe or kidney shaped
  • Usually necrosis and mitotic activity
  • Variants include small cell and lymphohistiocytic
Microscopic (histologic) images

Images hosted on other servers:

H&E, stains and molecular studies

Medium to large cells

Positive stains
Molecular / cytogenetics description
  • T cell receptor gene rearrangements
  • t(2;5) involving ALK1 and NPM
Differential diagnosis