CNS tumor
Astrocytic tumors
Anaplastic astrocytoma

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 24 August 2017, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: "Anaplastic astrocytoma" CNS

Cite this page: Abdelzaher, E. Anaplastic astrocytoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cnstumoranaplasticastrocytoma.html. Accessed September 19th, 2017.
Epidemiology
  • Mean age 45 years; male predominance
Sites
  • Usually supratentorial but can be anywhere in CNS; preferred sites are frontal and temporal lobes, brain stem, spinal cord; uncommon in cerebellum
Clinical features
Grading
  • WHO grade III
Radiology description
  • Neuroimaging: usually heterogeneous or patchy enhancement
Radiology images

Images hosted on other servers:

Anaplastic astrocytoma

Case reports
Gross description
  • Ill defined with blurred margins, may have spongy or gelatinous appearance, microcysts, calcification
  • May have clearer distinction from surrounding brain structures than low grade diffuse astrocytomas
Gross images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Similar to grade II tumors but more cellular, more atypia and mitoses are seen
  • By definition, vascular proliferation and necrosis are absent
Microscopic (histologic) images

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Various images

H&E and HAM56+ macrophages

p53

Positive stains
Molecular / cytogenetics description
Differential diagnosis