Benign / nonneoplastic lesions
Squamous papilloma

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 21 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Squamous papilloma cervix

Cite this page: Squamous papilloma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixsquamouspapilloma.html. Accessed August 18th, 2017.
Definition / general
  • Also called fibroepithelial polyp, fibroepithelial stromal polyp, mesodermal stromal polyp
  • Benign lesion of lower genital tract (vagina, vulva, less commonly in cervix), usually in women of reproductive age
  • 15%+ occur during pregnancy; these cases are often multiple with more pleomorphism and atypia
  • May contain atypical stromal cells (see Pseudosarcomatous fibroepithelial stromal polyp)
  • May regress spontaneously after delivery; may recur
  • May be a reactive hyperplastic process of myxoid stroma of lower female genital tract, because
    1. No clearly defined margin
    2. Stromal cells also present in normal vulva, vagina and cervix
    3. Similar lesions at other sites
    4. ER+ / PR+ suggests hormonal influence
  • May represent condyloma without koilocytosis
  • Excisional biopsy
Gross description
  • Usually 5 mm or less, solitary
Microscopic (histologic) description
  • Fibrovascular stalk covered by mature squamous epithelium, or acanthotic stellate shaped cells growing in a chaotic manner
  • Often no distinct boundary between stroma and epithelium
  • May have multinucleated stromal cells near epithelial-stromal interface or edematous stroma with occasional enlarged multinucleated fibroblasts
  • No arborizing pattern, no koilocytotic changes, no cambium layer, no rhabdomyoblasts, no / rare mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Not cervix:

Respiratory squamous papilloma

Images hosted on other servers:

Squamous epithelium overlying
fibrovascular papillae

Cytology description
Differential diagnosis