Premalignant / preinvasive lesions
Radiation atypia

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 14 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Radiation atypia cervix

Cite this page: Radiation atypia . PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixradiationatypia.html. Accessed October 23rd, 2017.
Definition / general
  • Can involve endocervical cells or squamous epithelial cells
Gross description
  • Fibrosis, induration, stenosis of endocervix, surface irregularity or no abnormality
Microscopic (histologic) description
  • Similar to changes in other organs (Int J Gynecol Pathol 1996;15:242)
  • Hyalinized stroma or reactive changes with ectatic vessels
  • Sparse, well spaced tubular or dilated glands in endocervix
  • Abundant cytoplasm with vacuoles
  • Uniformly dispersed nuclei with minimal crowding but marked nuclear atypia of endocervical glandular cells with enlarged, pleomorphic and smudged nuclei, prominent nucleoli
  • Chromatin is fine and degenerated
  • No / rare mitotic figures, low N/C ratio
Microscopic (histologic) images

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Radiation atypic

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Radiation atypic

Cytology description
Positive stains
  • Scattered CEA