Lymphoepithelioma-like carcinoma

Author:Branko Perunovic, M.D. (see Authors page)

Revised: 20 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Lymphoepithelioma-like carcinoma cervix

Cite this page: Cervix - Lymphoepithelioma-like carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixlymphoepithelioma.html. Accessed April 25th, 2017.
Definition / General
  • Resembles nasopharyngeal counterpart
  • Usually younger patients than squamous cell carcinoma of cervix
  • Uncommon, usually EBV+ in Asian patients (Cancer 1997;80:91); EBV- in non Asian patients (Arch Pathol Lab Med 2002;126:1501)
  • Usually low stage at diagnosis; better outcome than usual squamous cell carcinoma of cervix
Case Reports
Micro Description
  • Syncytium of large tumor cells with eosinophilic cytoplasm, vesicular nuclei, prominent nucleoli
  • Prominent lymphoplasmacytic infiltration with T lymphocytes
  • Pushing margins
  • No glandular or squamous differentiation
Micro Images

Images hosted on other servers:

H&E and stains

Syncytial pattern,
cells have
prominent nucleoli

CD45+ infiltrating lymphocytes


Well circumscribed tumor

Large epithelioid cells
with prominent nucleoli in
inflammatory background

Cytology Description
Positive Stains
Negative Stains
  • Lymphoid markers (stain infiltrating lymphocytes only), bcl2, ER, PR
Molecular / Cytogenetics Description
Differential Diagnosis