Cervix
Carcinoma
Large cell neuroendocrine carcinoma

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 20 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: large cell neuroendocrine carcinoma [title] cervix

Cite this page: Cervix - Large cell neuroendocrine carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixlargecellneuroendocrine.html. Accessed November 22nd, 2017.
Definition / general
  • Rare ( < 1% of cervical carcinomas)
  • Mean age 34 years, range 21 to 62 years
  • Presents with abnormal Pap smear or vaginal bleeding
  • Aggressive behavior, similar to lung counterpart, with early metastases to regional lymph nodes and liver, lung, bone and brain (Int J Gynecol Pathol 2003;22:226)
  • Median survival < 2 years
Case reports
Microscopic (histologic) description
  • Defined as moderate to severe nuclear atypia, neuroendocrine differentiation with cells larger than typical small cell carcinoma
  • Insular, trabecular, glandular and solid growth patterns
  • Usually eosinophilic cytoplasmic granules, > 10 MF/10 HPF and extensive necrosis
  • Angiolymphatic invasion
  • Often with adjacent adenocarcinoma in situ
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #327:

H&E


CK7

p16

Chromogranin

Synaptophysin



Images hosted on other servers:

Trabecular pattern with mitotic activity

With adenocarcinoma in situ

Metastatic to bone marrow

Keratin+ (MNF116)
in paranuclear
dot-like pattern

Synaptophysin+


Negative stains
Molecular / cytogenetics description
Electron microscopy images

Images hosted on other servers:

Pseudorosette

Differential diagnosis
Additional references