Cervix
Benign / nonneoplastic epithelial lesions
Endometriosis
Authors: Branko Perunovic, D.M., Marilin Rosa, M.D.
Last author update: 1 May 2007
Last staff update: 7 February 2024 (update in progress)
Copyright: 2007-2024, PathologyOutlines.com, Inc.
PubMed Search: Endometriosis cervix
See also Ovary topic
See subtype below: Stromal endometriosis
Table of Contents
Definition / general | Case reports | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Differential diagnosis | Additional references | Definition / general | Microscopic (histologic) description | Differential diagnosis | Additional referencesCite this page: Perunovic B, Rosa M. Endometriosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixendometriosis.html. Accessed April 19th, 2024.
Definition / general
- May cause abnormal uterine bleeding, postcoital bleeding
- Mean age 37 years, range 20 to 51 years
- Superficial endometriosis may be due to mechanical disruption of endometrium after D & C or cone biopsy
Case reports
- 46 year old woman with myxoid endometriosis simulating pseudomyxoma peritonea (Am J Surg Pathol 1994;18:849)
- 47 year old woman with superficial cervical endometriosis with florid smooth muscle metaplasia (Br Med J 1975;2:87)
Gross description
- Red / blue nodules
Microscopic (histologic) description
- Similar to endometriosis elsewhere
- Two of three present - endometrial glands with basal nuclei, spindled stroma, hemorrhage
- Usually involves superficial third of cervical wall, not deep wall
- Glands are evenly spaced and without atypia, are surrounded by stroma at least focally
- Inflammation and hemorrhage may obscure endometrial storm
- May have prominent mitotic activity
- No thick collagen bundles
Microscopic (histologic) images
AFIP images
Endometriosis
Cytology description
- Endometrial type cells in solid and cohesive clusters (may be tridimensional) with crowded, overlapping glandular groups, loss of cellular polarity and a frequent ragged "feathered" edge appearance with protruding nuclei (Diagn Cytopathol 2004;30:88)
- Also hemosiderin laden macrophages and sometimes spindle stromal cells
- No pseudostratified cell strips (Diagn Cytopathol 1999;21:188)
Positive stains
- CD10
- Reticulin surrounds each cell (Int J Gynecol Pathol 2001;20:173)
Differential diagnosis
- Adenocarcinoma in situ, invasive carcinoma: no endometrial stroma, marked atypia
- Endocervical glandular dysplasia
- Tuboendometrial metaplasia
Additional references
Definition / general
- Endometriotic stroma only with no/rare glands
- Mean age 43 years, range 29 to 64 years
Microscopic (histologic) description
- Well circumscribed foci within cervical superficial stroma containing endometrial stromal cells, small blood vessels, extravasated RBCs
- Usually no endometrial type glands
Differential diagnosis
Additional references
