Cervix - Cytology
Atypia / premalignant / preinvasive lesions
Radiation atypia

Author: Marilin Rosa, M.D. (see Authors page)

Revised: 14 April 2017, last major update June 2011

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PubMed search: Radiation atypia cervix

Cite this page: Radiation atypia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcytologyradiationatypia.html. Accessed September 25th, 2017.
Definition / general
  • Severe changes less than carcinoma
  • Clinical history is important
Cytology description
  • Usually low cellularity
  • Multinucleated giant cells, large atypical cells with marked cytoplasmic vacuoles
  • Intermediate parabasal cells have nuclear enlargement 2.5 to 3.0× normal but with low N/C ratio due to increased cytoplasm
  • Chromatin is smudgy or finely granular
  • Prominent nucleoli
  • Smear also shows endothelial cells and macrophages (Diagn Cytopathol 1995;13:107) but clean background
Cytology images

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