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Benign / non-neoplastic lesions

Lobular endocervical glandular hyperplasia of cervix, NOS

Reviewer: Farnaz Hasteh, M.D., UCSD Medical Center (see Reviewers page)
Revised: 20 September 2012, last major update December 2010
Copyright: (c) 2006-2012, PathologyOutlines.com, Inc.


● Pseudoneoplastic glandular lesion of cervix
● Not neoplastic (Am J Surg Pathol 1999;23:886)

Clinical features

● May be associated with endocervical adenocarcinoma (Mod Pathol 2005;18:1199)

Cytology description

● Hyperplastic glandular lesions with lobular arrangements, but no desmoplastic stroma
● Hyperplastic lesions are composed of high columnar mucinous cells with no atypia and no/rare mitotic figures
● Benign looking glandular cells have intracytoplasmic golden-yellow mucin (Diagn Cytopathol 2002;27:80)
● Intranuclear cytoplasmic inclusions usually are present

Cytology images

Microscopic images

Benign glandular cells with golden-yellow mucin (figures c and d)

Differential diagnosis

● Minimal deviation adenocarcinoma: may also have golden yellow mucin, but has focally malignant cytologic features, three dimensional cell clustering, prominent nucleoli, no intracellular cytoplasmic inclusions (Pathol Int 2005;55:412, Diagn Cytopathol 2008;36:535)

End of Cervix-cytology > Benign / non-neoplastic lesions > Lobular endocervical glandular hyperplasia of cervix, NOS

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