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Endometrial adenocarcinoma

Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 3 April 2014, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.

Clnical features

● Cervical smear is 45% sensitive in detecting endometrial adenocarcinoma (Acta Cytol 2003;47:410)
● Cervical smear is useful to detect cervical involvement of endometrial carcinoma (Acta Cytol 2002;46:284)
● Thin-Prep may be more sensitive than conventional smears (Cancer 2002;96:338, Diagn Cytopathol 2000;23:260)
● Low risk (<2%) of nodal spread if normal cervical smear (Obstet Gynecol 2003;101:445)

Cytology description

● Glandular component present
● Also scattered single cells with hyperchromatic nuclei, 1-3 nucleoli, mitotic figures, apoptotic bodies, watery diathesis
● Thin-Prep shows tumor diathesis (53%, usually high grade lesions, Diagn Cytopathol 2005;33:162)

Cytology images

Various images

Endometrial group with atypia (not necessarily carcinoma) in postmenopausal woman
Contributed by Dr. Carmen Luz, Spain

Contributed by: Marilin Rosa, MD, University of Florida

Positive stains

● Vimentin, estrogen receptor (Chu: Modern Immunohistochemistry, 2009)

Negative stains

● CEA, p16 (usually negative or only focally positive, Mod Pathol 2006;19:1091)

Differential diagnosis

Microglandular hyperplasia: no scattered single cells with atypia, no mitotic figures, no apoptotic bodies, no watery diatheses, CEA negative (Acta Cytol 2000;44:661)

End of Cervix-cytology > Carcinoma > Endometrial adenocarcinoma

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