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Normal cells / non-neoplastic findings


Reviewer: Xinmin Zhang, M.D., Temple University (see Reviewers page)
Revised: 14 June 2011, last major update August 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.

Definition / General

● Degenerative type changes due to delay in transfer of cells to the slide (air drying artifact), inflammation or atrophy
● More common on conventional than liquid based preparations


● Occasionally called retroplastic change

Cytology description

● Cytoplasm is lost and moth eaten with vacuolization
● Chromatin is clumped, hazy, smudged or indistinct
● Chromatin rim has variable thickness and irregular contours, but no sharp angles of malignancy

Cytology images

Degenerated cells

End of Cervix-cytology > Normal cells / non-neoplastic findings > Degeneration

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