Cervix - Cytology
Cytopathology Competency / Milestone Assessment
9. Human Papillomavirus (HPV)

Author: Ricardo R. Lastra M.D., Zubair W. Baloch, M.D. (see Authors page)

Revised: 24 May 2017, last major update January 2014

Copyright: (c) 2014-2017, PathologyOutlines.com, Inc.

PubMed search: "hpv cervix" cytology [title]

Cite this page: Human Papillomavirus (HPV). PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcytologycomphpv.html. Accessed May 28th, 2017.
Medical Knowledge
  1. Understand the pathophysiology of human papillomavirus (HPV) infection
  2. Recognize low risk and high risk HPV serotypes
  3. Recognize morphologic features of HPV infection (i.e. koilocytes)
  4. Describe the methods of detection of HPV infection
    • In situ hybridization
    • Southern blot technique
    • Polymerase chain reaction
    • Recognize atypical immature metaplasia
Practice Based Learning and Systems Based Practice
  1. Understand the effect of HPV infection according to the epithelium involved
    • Keratinized epithelium vs. mature metaplastic epithelium
  2. Understand that the nuclear features are the key in differentiating true koilocytes from changes seen in certain reactive processes
  3. Understand the type of epithelial cell abnormality and its prognosis according to the HPV serotype present
  4. Understand the sensitivity of the various methods of detection of HPV infection
  5. Understand the most appropriate method of detection of HPV infection to be used according to the clinical scenario
  6. Understand that HPV related changes can coexist with high grade dysplasia