Cervix - Cytology
Clear cell carcinoma

Author: Ashwyna Sunassee, M.D. (see Authors page)

Revised: 3 May 2017, last major update January 2015

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Clear cell carcinoma [title] cervix cytology
Cite this page: Clear cell carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcytologyclearcell.html. Accessed October 23rd, 2017.
Definition / general
  • DES associated: historically ages 14 to 22 years at diagnosis versus non-DES associated: ages 13-80 years
  • Due to ban on DES, DES associated clear cell carcinoma is extremely rare and generally affects older women
Cytology description
  • Pap test:
    • Cells are arranged in sheets, clusters or papillae
    • Cells have delicate vacuolated glycogen rich cytoplasm that may show naked nuclei and a tigroid background
    • Nuclei are large, pale, round with prominent nucleoli
  • FNA:
    • Loose, three dimensional clusters and sheet arrangement of atypical cells
    • Atypical cells are large with abundant, weakly stained cytoplasm
    • Round or oval nuclei with large nucleoli (Acta Cytol 2000;44:251)
Cytology images

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Conventional Pap test

Positive stains