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Normal cells / non-neoplastic findings

Blue blobs

Reviewer: Varsha Manucha, M.D. (see Reviewers page)
Revised: 28 September 2010, last major update August 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.


● Represent condensed mucus, degenerated bare nuclei or precipitating hematoxylin
● In post-menopausal women, represent parabasal/intermediate squamous cells with various degrees of degeneration (Acta Cytol 2000;44:547)
● May have "string of pearls” appearance on ThinPrep in postmenopausal atrophy (Diagn Cytopathol 2009;38:233)

Cytology description

● Dark blue, rounded, amorphous masses

Cytology images


Liquid based cytology with amorphous basophilic material

Positive stains

● Periodic acid-Schiff and methyl green pyronin, cytokeratin, epithelial membrane antigen and carcinoembryonic antigen (Acta Cytol 2000;44:547)

Negative stains

● Mucicarmine and calcium, vimentin and muscle specific actin (Acta Cytol 2000;44:547)

Electron microscopy descriptions

● Cellular skeletons with residual tonofilaments enmeshed within a loose cytoskeleton matrix and nuclei with variable degrees of degeneration (Acta Cytol 2000;44:547)

End of Cervix-cytology > Normal cells / non-neoplastic findings > Blue blobs

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