Cervix - Cytology
Carcinoma
Adenosquamous (mixed) carcinoma

Author: Ashwyna Sunassee, M.D. (see Authors page)
Editor: Ryan Askeland, M.D.

Revised: 24 April 2017, last major update December 2014

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Adenosquamous carcinoma [title] cervix
Cite this page: Adenosquamous (mixed) carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcytologyadenosquamous.html. Accessed June 27th, 2017.
Definition / general
Pathophysiology
Case reports
Treatment
  • Radical hysterectomy and chemoradiation
  • Cisplatin based chemoradiation - overall survival now comparable to squamous cell carcinoma of cervix, although historically poorer prognosis
  • Poorer prognosis with radiation alone (Gynecol Oncol 2014;135:208, Gynecol Oncol 2014;135:462)
Microscopic (histologic) images

Images hosted on other servers:
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Well differentiated

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Signet ring type

Cytology description
  • Thin - layer cytology, papillary subtype:
    • High cellularity
    • Multiple small, papillary clusters of basaloid to columnar cells
    • Discernible fibrovascular cores
    • Background of loosely dispersed bland looking columnar cells and high grade squamous intraepithelial lesion
    • Scattered adenocarcinoma cells containing intracytoplasmic vacuoles (Acta Cytol 2003;47:649)
Differential diagnosis