Cervix - Cytology
Carcinoma
Adenoid basal

Author: Ashwyna Sunassee, M.D. (see Authors page)
Editor: Ryan Askeland, M.D.

Revised: 3 May 2017, last major update November 2014

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Adenoid basal [title]
Cite this page: Cytology - Adenoid basal. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcytologyadenoidbasal.html. Accessed September 25th, 2017.
Definition / general
  • Very rare indolent tumor with favorable clinical course and excellent prognosis
  • Affects older postmenopausal women, often non - white
  • Usually diagnosed retrospectively on surgical specimens
  • Rare metastasis
Epidemiology
Pathophysiology
  • Genetic studies have shown correlation with viral infection, particularly HPV type 16 (Hum Pathol 2005;36:82)
  • p53 gene alterations including wild type hyperexpression and p53 point mutation damage have been noted
Etiology
Clinical features
  • ~80% of patients are asymptomatic at initial diagnosis
  • 80 - 90% come to clinical attention due to abnormal pap smear - usually a high - grade squamous intraepithelial lesion
Prognostic factors
  • Morphologically pure lesions usually have favorable outcome
Case reports
Gross description
  • Normal cervix without any obvious lesion
Microscopic (histologic) description
  • Nested cellular proliferations with peripheral palisading (Diagn Pathol 2006 Aug 16;1:20)
  • Uniform, round to oval cells with scant cytoplasm, hyperchromatic nuclei with inconspicuous nucleoli and minimal nuclear atypia
  • May have microcyst formation
  • No stromal reaction
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Basaloid cells infiltrating stroma

Missing Image

Small nests of round small cells

Missing Image

Small acini

Missing Image

Palisading arrangement

Missing Image

Scattered cellular proliferations

Missing Image

Ki67, p16


Missing Image

EMA

Cytology description
  • Often no findings or unrecognized on cytology, as many cases do not involve surface
  • Usually associated with HSIL, and hence detected on Pap; HPV16+
  • Three dimensional, somewhat dyscohesive groups of intact small and uniform cells with overlapping nuclei (Acta Cytol 1995;39:563)
  • Scant cytoplasm (Diagn Cytopathol 1996;14:172)
  • Occasional peripheral palisading
  • Finely granular chromatin, mild hyperchromasia, small / inconspicuous nucleoli
  • "Windswept appearance" when compared to reactive atypia (Acta Cytol 1995;39:563)
Positive stains
Negative stains
Differential diagnosis