Cervix - Cytology
Benign / nonneoplastic lesions
Microglandular hyperplasia

Author: Farnaz Hasteh, M.D. (see Authors page)

Revised: 20 April 2017, last major update December 2010

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PubMed search: Cervix Cytology Microglandular hyperplasia

Cite this page: Microglandular hyperplasia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcytologyMGH.html. Accessed October 20th, 2017.
Definition / general
  • Benign, nonneoplastic proliferation of endocervical glands
  • Common in reproductive aged women but can be also present after menopause
  • Associated with oral contraceptive pills (progestins), pregnancy
Cytology description
  • Uniform glandular cells with fenestration or microacini (Acta Cytol 1999;43:110)
  • Bi or tridimensional cellular clusters of cubic or cylindrical glandular cells with vacuolated cytoplasm, also cells with dense cytoplasm and basaloid cells
  • Often has an immature metaplastic pattern (Diagn Cytopathol 2004; 30:57)
  • Also reserve cells with scant cytoplasm and small, round nuclei
  • May have plasma cells or other inflammatory cells
  • May have cytologic atypia (Diagn Cytopathol 1994; 10:326) due to hyperchromatic crowded groups, nuclear enlargement, hyperchromasia
  • Cells may have multiple nucleoli, mitotic figures, apoptotic bodies and focal, watery diathesis (Acta Cytol 2000; 44:661)
Positive stains
Negative stains
Differential diagnosis