Premalignant / preinvasive lesions
Condyloma acuminatum

Author: Seema Khutti, M.D. (see Authors page)

Revised: 20 April 2017, last major update August 2013

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: Condyloma

See also: immature condyloma

Cite this page: Condyloma acuminatum. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixcondyloma.html. Accessed April 27th, 2017.
Definition / General
  • Cervical cancer precursor lesion (Int J Cancer 2006;119:888)
  • Subcategory of LSIL, also flat condyloma and CIN-I
  • Commonly sexually transmitted, peaks second and third decade
  • Tends to recur; enlarges during pregnancy; may regress without treatment
  • Also known as exophytic condyloma, mature exophytic LSIL
  • True prevalence unknown, up to 3.0% of Pap smears reported as SIL
  • Incidence may decrease in younger women following HPV vaccine (Am J Public Health 2012;102:833)
  • Transformation zone, exocervix
  • Strongly associated with HPV subtypes 6 and 11
Radiology Description
  • Raised polypoid or papillary lesion with prominent vasculature
  • Giant Condyloma: uncommon but important variant, presents as large tumor of cervix and distal vagina, misdiagnosed as verrucous carcinoma (Am J Surg Pathol 2013;37:300)
  • Excisional biopsy, diathermy or laser vaporization
Clinical Images

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Gross Description
  • Typically multifocal, white and exophytic; may be papillary
Micro Description
  • Characterized by verruciform growth pattern with blunt shaped papillae acanthosis, atypical parakeratosis and hyperkeratosis, koilocytosis in middle and upper epithelium, minor atypia is common
Micro Images

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Spiked excrescences

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Acanthosis, papillomatosis, koilocytosis 100x


Cervical condyloma is HPV+

Spiked excrescences

Cytology Description
Positive Stains
Negative Stains
Electron Microscopy Description
  • Viral particles contained in nuclei of superficial epithelial cells, most particles are single and either freely scattered throughout nucleoplasm or closely associated with chromatin clumps (J Clin Pathol 1981;34:532
Molecular / Cytogenetics Description
Differential Diagnosis
  • Filiform mucosal excrescences of vagina: no prominent acanthosis, no nuclear atypia, no atypical parakeratosis
  • Squamous papilloma: thick fibrovascular core, lacks hyperkeratosis and koilocytosis