Cervix
Sarcoma / lymphoma / other
Aggressive angiomyxoma

Author: Dr. Branko Perunovic (see Author page)

Revised: 28 April 2017, last major update May 2007

Copyright: (c) 2007-2015, PathologyOutlines.com, Inc.

PubMed Search: Aggressive angiomyxoma cervix

Cite this page: Aggressive angiomyxoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixaggressiveangio.html. Accessed June 22nd, 2017.
Definition / general
  • First described in female pelvis in 1983 (Am J Surg Pathol 1983;7:463)
  • Very rarely reported in cervix
  • Usually large, bulky mass of deep soft tissue of pelvicoperineal region of young adult women and men
  • High risk of local recurrence, but only rare metastases (Hum Pathol 2003;34:1072)
Gross description
  • Gelatinous, up to 60 x 20 cm, locally infiltrative
Microscopic (histologic) description
  • Bland-appearing myofibroblastic tumor composed of scanty spindled and stellate cells in loose stromal matrix with collagen fibrils, prominent vasculature including thick walled vessels
  • May infiltrate locally
  • No/rare mitotic figures, no atypia
Microscopic (histologic) images
Not necessarily cervix:

Bland hypocellular mesenchymal tumor

Negative stains
Molecular / cytogenetics description
  • Rearrangement of HMGIC gene
Electron microscopy description
  • Myofibroblastic features
Additional references