Adenosquamous carcinoma

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 24 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: adenosquamous carcinoma [title] cervix

Cite this page: Cervix - Adenosquamous carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixadenosquamous.html. Accessed September 25th, 2017.
Definition / general
  • May arise from subcolumnar reserve cells in basal layer of endocervix
  • More common during pregnancy
  • Same prognosis as other cervical carcinomas when stratified by grade and stage but most cases are high grade
  • Most undifferentiated cervical carcinomas have ultrastructural features of squamous or glandular differentiation
Case reports
Microscopic (histologic) description
  • Usually defined as biphasic pattern of well defined malignant glandular and squamous components clearly identifiable without special stains
  • Glandular component usually endocervical and poorly differentiated with cytoplasmic vacuoles or luminal mucin
  • Squamous component also is poorly differentiated
  • If endometrioid call endometrioid carcinoma with squamous differentiation
Microscopic (histologic) images

Images hosted on PathOut server:

Poorly formed glands and squamous components

Images hosted on other servers:

Various images

Cytology description
Positive stains
  • p63 (squamous component), CK7
Electron microscopy description
  • Glandular features include mucous secretory vacuoles, true lumen formation and scattered glycogen
  • Tonofilaments and secretory products
Differential diagnosis