Premalignant / preinvasive lesions
Stratified Mucin producing Intraepithelial Lesions (SMILE)

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 1 May 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Stratified Mucin producing Intraepithelial Lesions cervix

Cite this page: Stratified Mucin producing Intraepithelial Lesions (SMILE). PathologyOutlines.com website. http://pathologyoutlines.com/topic/cervixSMILE.html. Accessed July 24th, 2017.
Definition / general
  • Rare cervical intraepithelial lesion that is a variant of endocervical columnar cell neoplasia, consistent with neoplasm arising in reserve cells in transformation zone (Am J Surg Pathol 2000;24:1414)
  • Associated with SIL and invasive carcinoma
  • May be a marker of phenotype instability
Microscopic (histologic) description
  • Multilayered epithelium resembling SIL with conspicuous cytoplasmic clearing or vacuoles in lesions otherwise resembling HSIL due to more extreme nuclear pleomorphism and hyperchromasia and higher proliferation index
  • Mucin present throughout the epithelium
  • Usually associated SIL or AIS Usually no squamous differentiation
Microscopic (histologic) images

Images hosted on other servers:

Resembles HSIL but with abundant mucin

Positive stains
Negative stains