CD Markers
CD86

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD86[title]
Cite this page: CD86. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cdmarkerscd86.html. Accessed August 20th, 2017.
Definition / general
  • Also called B7-2
  • T cells need two signals for activation - the first signal is antigen peptide presented on MHC class II through the T cell receptor
  • The second (costimulatory) signal is delivered by CD80 or CD86, expressed on surface of antigen presenting cells, which interact with either CD28 or CD152 (CTLA-4)
  • CD80 and CD86 appear to have opposing functions on regulatory T cells (J Immunol 2004;172:2778)
  • Polymorphisms are associated with liver transplant acceptance (Transpl Immunol 2005;15:69) and systemic sclerosis (Int J Immunogenet 2006;33:155)
  • Increased expression may cause excessive antigen presentation in fulminant hepatic failure as an early step in its pathogenesis before the onset of tissue damage (Am J Pathol 1999;154:1711)
  • High circulating soluble levels are poor prognostic factor in myeloma (Br J Haematol 2006;133:165); are associated with severe asthma (Thorax 2004;59:870)
  • Receptor for some adenovirus species (Virus Res 2006;122:144)
  • Associated with H. pylori dependent early stage high grade MALT lymphoma of stomach (World J Gastroenterol 2005;11:4357)
Uses by pathologists
  • No significant clinical use by pathologists
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Microscopic (histologic) images

Images hosted on other servers:

Fig 1: thyroid carcinoma (E-H)

Positive staining - normal
  • Interdigitating dendritic cells in T zones of secondary lymphoid organs, Langerhans cells, peripheral blood dendritic cells, memory B cells, germinal center B cells, monocytes, endothelial cells, activated T cells
Positive staining - disease
Negative staining
  • Immature dendritic cells
Additional references