CD Markers
CD85

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD85

Related topics: CD85A, CD85B, CD85C, CD85D, CD85E, CD85F, CD85G, CD85H, CD85I, CD85J, CD85K, CD85L, CD85M
Cite this page: CD85. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cdmarkerscd85.html. Accessed December 9th, 2016.
Definition / General
  • Previously entire Immunoglobulin-like Transcript (ILT) family was clustered as CD85; now subclassified as CD85a to CD85m
  • Also called Leukocyte Immunoglobulin-like Receptors (LIR) and Monocyte/Macrophage Immunoglobulin-like Receptors (MIR)
  • CD85 itself is now called CD85J (see below)
  • Family of immunoreceptors expressed on monocytes and B cells; lower levels on dendritic cells and NK cells
  • Prevents NK / T cell killing and inhibits B cells by negative signaling receptors
  • Note: some family members have activating functions (see specific family members below)