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CD Markers
CD45

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 1 October 2013, last major update February 2011
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: CD45[title]

See also   CD45ROCD45RACD45RBCD45RC   below

General
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Physiology
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Clinical features
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Uses by pathologists
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Micro images
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Normal:

Liver: Kupffer cells,
lymphocytes (fig 2a)

Small intestine

Splenic lymphocytes


Left: thymus; right: tonsil



Lymphoma:

Left: B cell lymphoma-unusual CD45- case (fig B); right: CLL (fig 3a)


Left: diffuse large B cell lymphoma-urine cytology; middle: diffuse large B cell lymphoma-H&E (fig 7); right: Hodgkin’s-Reed-Sternberg cells are CD45- (fig 3C)


Nodular lymphocyte predominant Hodgkin lymphoma



Other:

Histiocytic sarcoma (fig C)

Leukemic vasculitis in the context of leukemia cutis,
in a patient with atypical chronic myeloid leukemia


Lymphoepithelioma-like carcinomas: tumor cells are CD45-, but infiltrating lymphocytes are CD45+
(left: stomach; right: cervix)


Left: leukemia cutis; right: myeloid sarcoma of fibula


Virtual slides
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Diffuse large B cell lymphoma

Positive staining - normal
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Positive staining - disease
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Negative staining
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Flow cytometry images
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Anaplastic large cell lymphoma


Transient myeloproliferative disorder with erythroid differentiation in Down’s syndrome (figure C)




CD45RO

General
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Physiology
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Uses by pathologists
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Micro images
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Hepatosplenic alpha-beta T cell lymphoma (fig C)

Multiple myeloma-plasma cell staining

CLL with prolymphocytic and Hodgkin’s lymphoma
transformation and CD45RO+ infiltrating T cells (fig 3)


NK/T cell lymphoma, nasal type (figure c)

NK-like T cell lymphoma of parotid gland of HIV+ man (fig 2B)


Peripheral T cell lymphoma: #1 (fig C); #2 (fig B)

Positive staining - normal
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Positive staining - disease
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Negative staining
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CD45RA

General
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Diagrams
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Subsets of T cells

Physiology
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Uses by pathologists
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Micro images
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Normal lymph node (B cells are positive, most T cells are negative, fig 4b)


Intraepidermal T Cells in fixed drug eruption lesions (fig d)


Papulonodular lesion show the dermal and intraepithelial neoplastic lymphocytes (fig C)

Positive staining - normal
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Positive staining - disease
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Negative staining
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CD45RB

General
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Diagrams
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CD45RB expression changes during germinal center reaction

Physiology
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Uses by pathologists
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Positive staining - normal
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Positive staining - disease
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Negative staining
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CD45RC

General
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Physiology
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Uses by pathologists
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Positive staining - normal
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Negative staining
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End of CD Markers > CD45


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