CD Markers
CD353

Author: Nat Pernick, M.D. (see Authors page)

Revised: 13 January 2016, last major update January 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: SLAMF8
Cite this page: CD353. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cdmarkerscd353.html. Accessed September 20th, 2017.
Definition / general
  • Also known as SLAMF8
  • First described at HLAD9 in 2011 (Immunol Lett 2011;134:104)
  • Member of CD2 family of cell surface proteins involved in lymphocyte activation (Wikipedia)
  • Cell surface receptor expressed upon activation of macrophages by IFN-γ or bacteria
  • Negatively regulates inflammatory responses via very high NADPH oxidase (Nox2) enzyme activity (J Immunol 2012;188:5829)
Clinical features
Uses by pathologists
  • None at this time
Positive staining - normal