CD Markers
CD26

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update June 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: cd26[title]

Cite this page: CD26. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cdmarkerscd26.html. Accessed May 23rd, 2017.
Definition / general
  • Widely expressive dipeptidase with various clinical features (see below)
Terminology
  • Also called dipeptidyl-peptidase IV, DPP4, DDPIV, adenosine deaminase complexing protein 2 (OMIM #102720)
Pathophysiology
  • Costimulatory molecule in T cell activation and proliferation
  • Also regulates various chemokines and cytokines
  • Cleaves amino-terminal dipeptides
  • Key role in cell adhesion and invasion (BMC Cancer 2013;13:517), plays a role in cell spreading and migration
  • Either soluble in plasma or present on cell surface
Clinical features
Uses by pathologists
  • No significant uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Colon: normal

Kidney: proximal tubules

Prostate: carcinoma

Skin: melanoma versus deep penetrating nevi

Positive staining - normal
  • Activated T and B cells, basophils, macrophages, NK cells, thymocytes (mature)
  • Epithelium: endometrium, hepatocytes, lung, prostate, renal proximal tubular cells, small intestine
  • Also cytotrophoblast and extravillous trophoblast (J Clin Endocrinol Metab 2002;87:4287), biliary canaliculae, endothelial cells, fibroblasts, mesothelial cells (Oncology 2002;63:158), splenic sinus lining cells
Positive staining - disease
Negative staining
  • Normal thyroid gland, T cells in peripheral blood of mycosis fungoides / cutaneous T cell lymphoma (40%, BMC Clin Pathol 2002;2:5)