CD Markers
CD25

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update July 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

Cite this page: CD25. PathologyOutlines.com website. http://pathologyoutlines.com/topic/cdmarkerscd25.html. Accessed August 18th, 2017.
Definition / general
  • Marker for hairy cell leukemia and systemic mastocytosis
Terminology
  • Also called IL-2 receptor alpha chain, IL2RA and TAC antigen (OMIM 147730)
Pathophysiology

Development of CD4+ CD25+ T cells

Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

HTLV1+ adult T cell leukemia / lymphoma

Mastocytosis

Tonsil



Images hosted on Flickr:

Hodgkin lymphoma



Images hosted on Nature.com:

Cutaneous T cell lymphoma

Hairy cell leukemia

Positive staining - normal
  • Activated B and T cells, macrophages, osteoblasts; some thymocytes, some myeloid precursors and some oligodendocytes; basophils have dim staining by flow cytometry (Arch Pathol Lab Med 2008;132:813)
Positive staining - disease
Negative staining
Flow cytometry Images

Hairy cell leukemia variant is CD103+ but CD25-