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Breast-nonmalignant
Benign tumors / changes
Tubular adenoma of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 9 October 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Benign nodules formed by the compact proliferation of tubular structures with 2 cell layers
Terminology
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● Tubular-fibroadenoma: both components are conspicuous and are at least 10% of the lesion
Epidemiology
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● Rare
● Usually young women, occasionally older women (Breast Cancer 2000;7:169)
Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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● 26 year old woman with 4 cm mass (Arch Pathol Lab Med 1983;107:84)
● 55 year old woman with adjacent invasive ductal carcinoma (Pathol Int 2002;52:244)
● 84 year old woman (Breast J 2006;12:257)
Treatment
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● Excision, does not recur
Clinical images
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Gross description (Macroscopy)
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● Solitary, well-circumscribed, tan-yellow, soft to firm mass
Gross images
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Micro description (Histopathology)
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● Closely packed uniform small tubules lined by single layer of epithelial cells and attenuated myoepithelium; sparse stroma
● May have lymphocytic infiltrate, no atypia
Micro images
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Ducts of uniform size Tubular adenoma pattern above, fibroadenoma pattern below
H&E p63 staining Myosin staining
Microcalcifications Tubular adenoma with ALH
Other images: circumscribed tumor with packed acini #1; #2
Drawings
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Virtual Slides
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Videos
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Cytology description
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● Three-dimensional cohesive balls of ductal cells and tubular structures in highly cellular smears
● Myoepithelial cells are present with sheets of ductal cells and as bipolar naked nuclei
● May have staghorn pattern of ductal cells
● No/scanty stroma (Cytopathology 1998;9:301)
Cytology images
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Positive stains
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Epithelial cells:
● EMA, ER, PR
Myoepithelial cells:
● Smooth muscle actin, vimentin (Pathol Res Pract 1995;191:1222)
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Adenomyoepithelioma, tubular variant: prominent myoepithelium, not well circumscribed
● Fibroadenoma: more stroma, less epithelium
● Infiltrating ductal carcinoma: irregular tubules, atypia, desmoplasia, infiltrative
Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Tubular adenoma
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